DAO-IN-2

DAO-IN-2 is a d-amino acid oxidase (DAO) inhibitor (h-DAO IC50 = 245 nM) . DAO-IN-2 is a moderate inhibitor of DAAO in vitro and in vivo. DAO-IN-2 can be used to study DAAO-related psychiatric disorders[1][2].

Product Specifications

CAS Number

[39793-31-2]

Product Name Alternative

Setogepram (sodium); PBI-4050 (sodium)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dao-in-2.html

Purity

99.95

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(C=CS2)N1)O

Molecular Formula

C7H5NO2S

Molecular Weight

167.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Tim Sparey, et, al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008,18, 11.|[2]Smith SM, et al. The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. J Pharmacol Exp Ther. 2009 Mar;328 (3) :921-30.