GPR84 antagonist 2
GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM) . GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
Product Specifications
CAS Number
[2244269-74-5]
UNSPSC
12352005
Target
GPR84
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gpr84-antagonist-2.html
Concentration
10mM
Purity
99.06
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)O[Na]
Molecular Formula
C28H16Cl2NaO4PS2
Molecular Weight
605.42
References & Citations
[1]Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65 (5) :3991-4006.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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