Human Immunoglobulin G4-Fc Antibody

<strong>Human Immunoglobulin G4-Fc Antibody</strong>_x000D_ <strong>Catalog number:</strong> B2015775_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> IgG4, ig, immunoglobuling4, immunoglobulin g4, immunoglobulin gIV, igg, IGHG4, IGHG 4, immunoglobulin, Ig gamma 4 Chain C Region, IGHG4, Immunoglobulin Heavy Constant Gamma 4, MGC117419, G4m Marker_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Davies AM, Sutton BJ. Human IgG4: a structural perspective Immunol Rev. 2015 Nov;268(1):139-59._x000D_ 2: Schlothauer T, Herter S, Koller CF, Grau-Richards S, Steinhart V, Spick C, Kubbies M, Klein C, Umaña P, Mössner E. Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions Protein Eng Des Sel. 2016 Oct;29(10):457-466._x000D_ 3: Davies AM, Rispens T, Ooijevaar-de Heer P, Aalberse RC, Sutton BJ. Room temperature structure of human IgG4-Fc from crystals analysed in situ Mol Immunol. 2017 Jan;81:85-91._x000D_ 4: Davies AM, Jefferis R, Sutton BJ. Crystal structure of deglycosylated human IgG4-Fc Mol Immunol. 2014 Nov;62(1):46-53._x000D_ 5: Hudecek M, Lupo-Stanghellini MT, Kosasih PL, Sommermeyer D, Jensen MC, Rader C, Riddell SR. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells Clin Cancer Res. 2013 Jun 15;19(12):3153-64._x000D_ 6: Davies AM, Rispens T, Ooijevaar-de Heer P, Gould HJ, Jefferis R, Aalberse RC, Sutton BJ. Structural determinants of unique properties of human IgG4-Fc J Mol Biol. 2014 Feb 6;426(3):630-44._x000D_ 7: Rispens T, Ooievaar-De Heer P, Vermeulen E, Schuurman J, van der Neut Kolfschoten M, Aalberse RC. Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions J Immunol. 2009 Apr 1;182(7):4275-81._x000D_ 8: Partridge MA, Chen J, Karayusuf EK, Sirimanne T, Stefan C, Lai CH, Gathani M, DeStefano L, Rozanski M, McAfee S, Rajadhyaksha M, Andisik MD, Torri A, Sumner G. Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay AAPS J. 2022 Jul 1;24(4):78._x000D_ 9: Sanford M. Dulaglutide: first global approval Drugs. 2014 Nov;74(17):2097-103._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/23567207">10: Wilkinson IC, Fowler SB, Machiesky L, Miller K, Hayes DB, Adib M, Her C, Borrok MJ, Tsui P, Burrell M, Corkill DJ, Witt S, Lowe DC, Webster CI. Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure MAbs. 2013 May-Jun;5(3):406-17. </a>_x000D_ _x000D_ <strong>Products Related to Human Immunoglobulin G4-Fc Antibody can be found at</strong> <a href="https://moleculardepot.com/product-category/Antibodies/"> Antibodies</a>