PKI (5-24)
PKI (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI (5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].
Product Specifications
CAS Number
99534-03-9
UNSPSC
12352209
Target
PKA
Type
Peptides
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pki-5-24.html
Purity
99.99
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
OC(C[C@@H](C(O)=O)NC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](N)[C@H](O)C)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C94H148N32O31
Molecular Weight
2222.38
References & Citations
[1]Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261 (3) :989-992.|[2]Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI (5-24) . Biol Chem. 1996;377 (7-8) :513-520.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400326-500 1x 500 µL
Serum Amyloid A (SAA/326), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
