PKI (5-24)

PKI (5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI (5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

Product Specifications

CAS Number

[99534-03-9]

UNSPSC

12352209

Target

PKA

Type

Peptides

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pki-5-24.html

Purity

99.99

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

OC(C[C@@H](C(O)=O)NC([C@H](CC1=CN=CN1)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](N)[C@H](O)C)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C94H148N32O31

Molecular Weight

2222.38

References & Citations

[1]Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261 (3) :989-992.|[2]Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI (5-24) . Biol Chem. 1996;377 (7-8) :513-520.