GMQ (hydrochloride)
GMQ (hydrochloride) is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ (hydrochloride) opens only ASIC3 but no other ASICs at pH 7.4. GMQ (hydrochloride) can be used for neurological disease research[1].
Product Specifications
CAS Number
5361-15-9
Product Name Alternative
2-Guanidine-4-methylquinazoline (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gmq.html
Purity
99.86
Solubility
H2O : 3.33 mg/mL (ultrasonic)
Smiles
CC1=NC(NC(N)=N)=NC2=CC=CC=C12.Cl
Molecular Formula
C10H12ClN5
Molecular Weight
237.69
Precautions
H315, H319, H335
References & Citations
[1]Alijevic O, Kellenberger S. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem. 2012 Oct 19;287 (43) :36059-70.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TRC-I781040-10G 10 g
2-Isobutyryl-N-phenyl-3-phenylacrylamide (E/Z mixture)
Sign In for Pricing
View Details 
LY423367 100 µg
C6orf226 (NM_001008739) Human Over-expression Lysate
Sign In for Pricing
View Details 
