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GMQ (hydrochloride)

GMQ (hydrochloride) is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ (hydrochloride) opens only ASIC3 but no other ASICs at pH 7.4. GMQ (hydrochloride) can be used for neurological disease research[1].

Product Specifications

CAS Number

5361-15-9

Product Name Alternative

2-Guanidine-4-methylquinazoline (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gmq.html

Purity

99.86

Solubility

H2O : 3.33 mg/mL (ultrasonic)

Smiles

CC1=NC(NC(N)=N)=NC2=CC=CC=C12.Cl

Molecular Formula

C10H12ClN5

Molecular Weight

237.69

Precautions

H315, H319, H335

References & Citations

[1]Alijevic O, Kellenberger S. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem. 2012 Oct 19;287 (43) :36059-70.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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