BT173

BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 and does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway. BT173 can be studied in research for kidney diseases such as renal fibrosis[1].

Product Specifications

CAS Number

[2232180-74-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

DYRK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bt173.html

Purity

98.71

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C2C=C(C3=NC(C4=CC=C(Br)C=C4)=NO3)C=NC2=C1

Molecular Formula

C18H12BrN3O2

Molecular Weight

382.21

Precautions

H315, H319, H320

References & Citations

[1]Ruijie Liu, et al. A Novel Inhibitor of Homeodomain Interacting Protein Kinase 2 Mitigates Kidney Fibrosis through Inhibition of the TGF- β 1/Smad3 Pathway. J Am Soc Nephrol. 2017 Jul;28 (7) :2133-2143.