Sarafotoxin S6c

Sarafotoxin S6c (SRTX-c) is a potent endothelin-B receptor agonist. Sarafotoxin S6c can cause vasoconstriction in both endothelium-intact and endothelium-denuded vessels[1].

Product Specifications

CAS Number

[121695-87-2]

Product Name Alternative

SRTX-c

UNSPSC

12352209

Hazard Statement

H300+H330

Target

Endothelin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sarafotoxin-s6c.html

Purity

98.19

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@]2([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC2)([H])NC([C@](NC([C@H](CSSC1)N)=O)([H])[C@H](O)C)=O)=O)CC(N)=O)=O)CC(O)=O)=O)CCSC)=O)([H])[C@H](O)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)N[C@@H](CC4=CN=CN4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O

Molecular Formula

C103H147N27O37S5

Molecular Weight

2515.75

Precautions

H300+H330

References & Citations

[1]MacLean MR, et al. Effects of pulmonary hypertension on vasoconstrictor responses to endothelin-1 and sarafotoxin S6C and on inherent tone in rat pulmonary arteries. J Cardiovasc Pharmacol. 1995 Nov;26 (5) :822-30.