Damulin B

Damulin B is a dammarane-type saponin found in Gynostemma pentaphyllum. Damulin B can inhibit cancer cell apoptosis, decrease mitochondrial membrane potential, inhibit ROS production and cause G0/G1 phase arrest. Damulin B can prevent Cisplatin (HY-17394) -induced acute kidney injury and induce hair growth. Damulin B shows anti-inflammation anti-diabetic and anti-obesity effect. Damulin B can be used for the researches of cancer, inflammation, metabolic disease, such as lung cancer, osteoarthritis and diabetes[1][2][3][4][5][6].

Product Specifications

CAS Number

[1202868-75-4]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; CDK; Interleukin Related; MDM-2/p53; MMP; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/damulin-b.html

Purity

97.89

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O[C@@H]([C@@H]([C@@H](CO)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@H]1O[C@H]3[C@H](O)C[C@]4(C)[C@@]5([H])C[C@@H](O)[C@@H]6[C@@H](C(CC/C=C(C)\C)=C)CC[C@@]6(C)[C@@](C)5CC[C@@]4([H])C3(C)C

Molecular Formula

C42H70O13

Molecular Weight

783.00

References & Citations

[1]Shao-Fang Xing, et al. Inhibitory Effect of Damulin B from Gynostemma pentaphyllum on Human Lung Cancer Cells. Planta Med. 2019 Mar;85 (5) :394-405.|[2]Song M, et al. A Hydrodistillate of Gynostemma pentaphyllum and Damulin B Prevent Cisplatin-Induced Nephrotoxicity In Vitro and In Vivo via Regulation of AMPKα1 Transcription. Nutrients. 2022 Nov 24;14 (23) :4997.|[3]Kovale L, et al. Gynostemma pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth-Inducing Properties In Vivo and In Vitro via the Wnt/β-Catenin Pathway in Dermal Papilla Cells. Nutrients. 2024 Mar 28;16 (7) :985.|[4]Lee SA, et al. Inhibitory Effects of Heat-Processed Gynostemma pentaphyllum Extract (Actiponin®) and Its Components on Cartilage Breakdown in Osteoarthritis. Int J Mol Sci. 2025 Feb 18;26 (4) :1728.|[5]Xu S, et al. Metabolomics and molecular docking-directed anti-obesity study of the ethanol extract from Gynostemma pentaphyllum (Thunb.) Makino. J Ethnopharmacol. 2024 Nov 15;334:118577.|[6]Nguyen PH, et al. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. 2011 Nov 1;19 (21) :6254-60.