Musk ketone

Musk ketone is a widely used artificial fragrance. Musk ketone is also a cytochrome P450 enzyme inducer. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].

Product Specifications

CAS Number

[81-14-1]

UNSPSC

12352005

Hazard Statement

H225, H302, H312, H319, H332, H351, H410

Target

Akt; Apoptosis; Cytochrome P450; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/musk-ketone.html

Purity

99.81

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CC(C1=C(C)C([N+]([O-])=O)=C(C(C)(C)C)C([N+]([O-])=O)=C1C)=O

Molecular Formula

C14H18N2O5

Molecular Weight

294.31

Precautions

H225, H302, H312, H319, H332, H351, H410

References & Citations

[1]Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26 (5) :656-62. |[2]Mersch-Sundermann V, et al. Musk ketone enhances benzo (a) pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495 (1-2) :89-96. |[3]Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9.|[4]Lehman-McKeeman LD, et al. Effects of musk xylene and musk ketone on rat hepatic cytochrome P450 enzymes. Toxicol Lett. 1999 Dec 20;111 (1-2) :105-15.|[5]An J, et al. Musk ketone induces apoptosis of gastric cancer cells via downregulation of sorbin and SH3 domain containing 2. Mol Med Rep. 2021 Jun;23 (6) :450.