MNK inhibitor 9
MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1].
Product Specifications
CAS Number
1889336-59-7
UNSPSC
12352005
Target
MNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mnk-inhibitor-9.html
Purity
99.38
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(C2=NC(C3=NC4=CC=CC(N5C[C@H](C)NCC5)=C4N3C)=C(N)N=C2)=NC=C1)N(C)C
Molecular Formula
C25H29N9O
Molecular Weight
471.56
References & Citations
[1]Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59 (7) :3034-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MNK1; MNK2
Available Sizes
Frequently Asked Questions
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