MNK inhibitor 9

MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research[1].

Product Specifications

CAS Number

[1889336-59-7]

UNSPSC

12352005

Target

MNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mnk-inhibitor-9.html

Purity

99.38

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC(C2=NC(C3=NC4=CC=CC(N5C[C@H](C)NCC5)=C4N3C)=C(N)N=C2)=NC=C1)N(C)C

Molecular Formula

C25H29N9O

Molecular Weight

471.56

References & Citations

[1]Han W, et al. Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design. J Med Chem. 2016 Apr 14;59 (7) :3034-45.