(1S,3R,5R) -PIM447 (dihydrochloride)

(1S,3R,5R) -PIM447 (dihydrochloride) an PIM inhibitor extracted from patent US 20100056576 A1, compound example 72, has IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.

Product Specifications

Product Name Alternative

(1S,3R,5R) -LGH447 dihydrochloride

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_1S,3R,5R_-PIM447-dihydrochloride.html

Purity

99.81

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)

Smiles

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@@H]4C[C@H](N)C[C@H](C)C4)C=CN=C3.Cl.Cl

Molecular Formula

C24H25Cl2F3N4O

Molecular Weight

513.38

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PIM1; PIM2; PIM3

Available Sizes

Curated Selection

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