Z4P
Product Specifications
UNSPSC Description
Z4P is a BBB-penatrable IRE1 inhibitor with an IC50 of 1.13 μM. Z4P in combination with Temozolomide (HY-17364) inhibits the growth and recurrence of glioblastoma and has anti-tumor activity[1].
Target Antigen
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z4p.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(CCC1=CC=C(C=C1)O)C)NC2=CC(C)=CC=C2C
Molecular Weight
312.41
References & Citations
[1]Pelizzari-Raymundo D, et al. A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment. iScience. 2023 Apr 24;26(5):106687.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153773/Z4P-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153773/Z4P-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2361760-87-2
Available Sizes
Curated Selection
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