Z4P
Z4P is a BBB-penetrable IRE1 inhibitor with an IC50 of 1.13 μM. Z4P in combination with Temozolomide (HY-17364) inhibits the growth and recurrence of glioblastoma and has anti-tumor activity[1].
Product Specifications
CAS Number
[2361760-87-2]
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z4p.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC(CCC1=CC=C(C=C1)O)C)NC2=CC(C)=CC=C2C
Molecular Formula
C19H24N2O2
Molecular Weight
312.41
References & Citations
[1]Pelizzari-Raymundo D, et al. A novel IRE1 kinase inhibitor for adjuvant glioblastoma treatment. iScience. 2023 Apr 24;26 (5) :106687.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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