Marasmic acid
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α, β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.
Product Specifications
CAS Number
2212-99-9
UNSPSC
12352005
Target
Bacterial; Fungal
Type
Natural Products
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/marasmic-acid.html
Smiles
O=CC1=C[C@]2([H])CC(C)(C)C[C@]2([H])[C@]34C(O[C@H](O)[C@@]31C4)=O
Molecular Formula
C15H18O4
Molecular Weight
262.30
References & Citations
[1]Hog1p activation by marasmic acid through inhibition of the histidine kinase Sln1p
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
RBMS1 (RNA-binding Motif, Single-stranded-interacting Protein 1, Single-stranded DNA-binding Protein MSSP-1, Suppressor of CDC2 with RNA-binding Motif 2, C2orf12, MSSP, MSSP1, SCR2, MGC15146, MGC3331) (HRP)
