Terephthalic acid

Terephthalic acid is an isomer and a precursor of polyester PET, which can be used to make clothing and plastics. Terephthalic acid can be used to build skin tumor models[1].

Product Specifications

CAS Number

[100-21-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Terephthalic_acid.html

Purity

99.99

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(C(O)=O)C=C1

Molecular Formula

C8H6O4

Molecular Weight

166.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Heck HD, et al. The induction of bladder stones by terephthalic acid, dimethyl terephthalate, and melamine (2,4,6-triamino-s-triazine) and its relevance to risk assessment. Regul Toxicol Pharmacol. 1985 Sep;5 (3) :294-313.|[2]Saito M, et al. CENP-50 is required for papilloma development in the two-stage skin carcinogenesis model. Cancer Sci. 2020 Aug;111 (8) :2850-2860.|[3]Cui L, et al. Deregulation of the p16-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway involved in the rat bladder carcinogenesis induced by terephthalic acid-calculi. Urol Res. 2006 Oct;34 (5) :321-8.|[4]Ball GL, et al. Toxicological review and oral risk assessment of terephthalic acid (TPA) and its esters: A category approach. Crit Rev Toxicol. 2012 Jan;42 (1) :28-67.