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Surfen (dihydrochloride)

Product Specifications

Product Name Alternative

Aminoquinuride (dihydrochloride)

UNSPSC Description

Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

Target Antigen

FGFR; HSV; VEGFR

Type

Reference compound

Related Pathways

Anti-infection;Protein Tyrosine Kinase/RTK

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/surfen-dihydrochloride.html

Purity

99.0

Solubility

H2O : 8 mg/mL (ultrasonic;warming)

Smiles

O=C(NC1=CC=C2N=C(C)C=C(N)C2=C1)NC3=CC=C4N=C(C)C=C(N)C4=C3.Cl.Cl

Molecular Weight

445.34

References & Citations

[1]Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-122704A/Surfen-dihydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-122704A/Surfen-dihydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

5424-37-3

Available Sizes

Curated Selection

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