Surfen (dihydrochloride)

Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE[1][2][3][4][5][6].

Product Specifications

CAS Number

[5424-37-3]

Product Name Alternative

Aminoquinuride (dihydrochloride)

UNSPSC

12352005

Target

FGFR; HSV; Tau Protein

Type

Reference compound

Related Pathways

Anti-infection; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/surfen-dihydrochloride.html

Concentration

10mM

Purity

99.93

Solubility

H2O : 8 mg/mL (ultrasonic; warming) |DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C2N=C(C)C=C(N)C2=C1)NC3=CC=C4N=C(C)C=C(N)C4=C3.Cl.Cl

Molecular Formula

C21H22Cl2N6O

Molecular Weight

445.34

References & Citations

[1]Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105 (35) :13075-80.|[2]Huang ML, et al. Small Molecule Antagonist of Cell Surface Glycosaminoglycans Restricts Mouse Embryonic Stem Cells in a Pluripotent State. Stem Cells. 2018 Jan;36 (1) :45-54.|[3]Varatharajan A, et al. Visual determination of heparin in serum utilizing surfen-induced aggregation emission enhancement of gold nanoclusters and heparin-induced fluorescence enhancement of surfen. Spectrochim Acta A Mol Biomol Spectrosc. 2025 Apr 15;339:126251.|[4]Alavi Naini SM, et al. Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy. Transl Neurodegener. 2018 Mar 16;7:6.|[5]Warford JR, et al. Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis. Acta Neuropathol Commun. 2018 Jan 4;6 (1) :4.|[6]Warford J, et al. Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide) . Biochem Biophys Res Commun. 2014 Jan 10;443 (2) :524-30.