ADX71743
Product Specifications
UNSPSC Description
ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 has anxiolytic-like activity[1][2].
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/adx71743.html
Purity
99.30
Solubility
10 mM in DMSO|DMSO : 5 mg/mL (ultrasonic;warming)
Smiles
O=C1C2=C(OC(CC)=N2)CC(C3=C(C=C(C)C=C3)C)C1
Molecular Weight
269.34
References & Citations
[1]Rebecca Klar, et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci. 2015 May 13;35(19):7600-15.|[2]Mikhail Kalinichev , et al. ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and in Vivo Characterization. Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110278/ADX71743-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110278/ADX71743-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1431641-29-0
Available Sizes
Curated Selection
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