ADX71743

ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) . ADX71743 has anxiolytic-like activity[1][2].

Product Specifications

CAS Number

[1431641-29-0]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/adx71743.html

Purity

99.30

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(OC(CC)=N2)CC(C3=C(C=C(C)C=C3)C)C1

Molecular Formula

C17H19NO2

Molecular Weight

269.34

References & Citations

[1]Rebecca Klar, et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci. 2015 May 13;35 (19) :7600-15.|[2]Mikhail Kalinichev , et al. ADX71743, a Potent and Selective Negative Allosteric Modulator of Metabotropic Glutamate Receptor 7: In Vitro and in Vivo Characterization. Pharmacol Exp Ther. 2013 Mar;344 (3) :624-36.