306Oi10

306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery[1][2].

Product Specifications

CAS Number

[2322290-93-5]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/306oi10.html

Purity

98.07

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(CCN(CCCN(CCCN(CCC(OCCCCCCCC(C)C)=O)CCC(OCCCCCCCC(C)C)=O)C)CCC(OCCCCCCCC(C)C)=O)OCCCCCCCC(C)C

Molecular Formula

C59H115N3O8

Molecular Weight

994.56

Precautions

H225, H319

References & Citations

[1]Hajj K A. Lipid Nanoparticle Systems for the Delivery of Messenger RNA. Carnegie Mellon University, 2019.|[2]Hajj KA, et al. Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH. Small. 2019 Feb;15 (6) :e1805097. doi: 10.1002/smll.201805097.