ZXH-3-26
ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM[1].
Product Specifications
CAS Number
[2243076-67-5]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ZXH-3-26.html
Purity
98.90
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1
Molecular Formula
C38H37ClN8O7S
Molecular Weight
785.27
Precautions
H302, H312, H332
References & Citations
[1]Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul;14 (7) :706-714.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Cereblon
Available Sizes
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