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Acyclovir (hydrochloride)

Acyclovir (Aciclovir) hydrochloride is a potent, orally active antiviral agent. Acyclovir hydrochloride has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir hydrochloride induces cell cycle perturbation and apoptosis. Acyclovir hydrochloride prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

Product Specifications

CAS Number

1628039-62-2

Product Name Alternative

Aciclovir (hydrochloride) ; Acycloguanosine (hydrochloride)

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial; HSV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/acyclovir-hydrochloride.html

Smiles

O=C1N=C(NC2=C1N=CN2COCCO)N.Cl

Molecular Formula

C8H12ClN5O3

Molecular Weight

261.67

References & Citations

[1]Benedetti S, et, al. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity. Life Sci. 2018 Dec 15;215:80-85.|[2]Suzuki M, et, al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res. 2006 Nov;72 (2) :157-61.|[3]Li Z, et, al. Acyclovir treatment of skin lesions results in immune deviation in mice infected cutaneously with herpes simplex virus. Antivir Chem Chemother. 1999 Sep;10 (5) :251-7.|[4]Lönnqvist B, et, al. Oral acyclovir as prophylaxis for bacterial infections during induction therapy for acute leukaemia in adults. The Leukemia Group of Middle Sweden. Support Care Cancer. 1993 May;1 (3) :139-44.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 4

Frequently Asked Questions

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