GW0072
Product Specifications
UNSPSC Description
GW0072 is a partial agonist of PPARγ and does not directly bind to the AF-2 helix of PPARγ, resulting in specific partial receptor transcriptional activation properties[1][2].
Target Antigen
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gw0072.html
Smiles
O=C(C1=CC=C(C=C1)CCCCN2[C@@H](S[C@H](C2=O)CC(N(CC3=CC=CC=C3)CC4=CC=CC=C4)=O)CCCCCCC)O
Molecular Weight
614.84
References & Citations
[1]Ligand entry pathways in the ligand binding domain of PPARc receptor|[2]Genest D, et al. Ligand-escape pathways from the ligand-binding domain of PPARgamma receptor as probed by molecular dynamics simulations. Eur Biophys J. 2008 Apr;37(4):369-79. |[3]Zhang F, et al. Selective Modulators of PPAR-gamma Activity: Molecular Aspects Related to Obesity and Side-Effects. PPAR Res. 2007;2007:32696.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118097/GW0072-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118097/
Clinical Information
No Development Reported
CAS Number
321557-86-2
Curated Selection
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