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Taltobulin intermediate-4

Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin. Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

Product Specifications

CAS Number

187345-37-5

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/taltobulin-intermediate-4.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)[C@@H](/C=C(C)/C(OCC)=O)N(C([C@H](C(C)(C)C)NC(OC(C)(C)C)=O)=O)C

Molecular Formula

C22H40N2O5

Molecular Weight

412.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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