Iptakalim (hydrochloride)

Iptakalim hydrochloride, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist[1].

Product Specifications

CAS Number

[642407-63-4]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

NAChR; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/iptakalim-hydrochloride.html

Purity

98.0

Solubility

H2O : 25 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

CC(C)NC(C)(C)C(C)C.Cl

Molecular Formula

C9H22ClN

Molecular Weight

179.73

Precautions

H315, H319, H335

References & Citations

[1]Mengyu He, et al. Iptakalim ameliorates hypoxia-impaired human endothelial colony-forming cells proliferation, migration, and angiogenesis via Akt/eNOS pathways. Pulm Circ. 2019 Oct 18;9 (3) :2045894019875417.|[2]Weiping Xie, et al. Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells. Eur J Pharmacol. 2005 Mar 28;511 (2-3) :81-7.|[3]S Charntikov, et al. Iptakalim attenuates self-administration and acquired goal-tracking behavior controlled by nicotine. Neuropharmacology. 2013 Dec;75:138-44.