6-Hydroxykynurenic acid

6-Hydroxykynurenic acid (6-HKA) is a derivative of kynurenic acid (KYNA) and can be isolated from Ginkgo leaves. 6-Hydroxykynurenic acid is a low-affinity NMDAR antagonist (IC50: 59 μM) [1].

Product Specifications

CAS Number

[3778-29-8]

Product Name Alternative

6-HKA

UNSPSC

12352005

Target

IGluR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/6-hydroxykynurenic-acid.html

Purity

99.60

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(O)=C2C=C(O)C=CC2=N1)O

Molecular Formula

C10H7NO4

Molecular Weight

205.17

References & Citations

[1]Weber M, et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77 (4) :1108-15.|[2]Weber M. et al. 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. J Neurochem. 2001 May;77 (4) :1108-15.