L-DABA (hydrobromide)

L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro.

Product Specifications

CAS Number

[73143-97-2]

Product Name Alternative

L-2,4-Diaminobutyric acid (hydrobromide)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-daba-hydrobromide.html

Purity

98.0

Solubility

DMSO : 23 mg/mL (ultrasonic)

Smiles

NCC[C@H](N)C(O)=O.[H]Br

Molecular Formula

C4H11BrN2O2

Molecular Weight

199.05

Precautions

H302, H315, H319, H335

References & Citations

[1]Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96 (3) :259-68.|[2]Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5 (3-4) :193-8.|[3]Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21 (2) :143-4.