PI3K/mTOR Inhibitor-2

PI3K/mTOR Inhibitor-2 is a potent dual pan-PI3K/mTOR inhibitor with IC50s of 3.4/34/16/1 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ and 4.7 nM for mTOR[1]. Antitumor activity[1].

Product Specifications

CAS Number

[1848242-58-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PI3K-mTOR_Inhibitor-2.html

Concentration

10mM

Purity

99.10

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

FC1=CC(F)=C(S(=O)(NC2=CC(C(C=C3)=CN4C3=NC=C(Cl)C4=O)=CN=C2OC)=O)C=C1

Molecular Formula

C20H13ClF2N4O4S

Molecular Weight

478.86

Precautions

H302, H315, H319

References & Citations

[1]Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9 (3) :256-261.