TH10785
Product Specifications
UNSPSC Description
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/th10785.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1
Molecular Weight
267.37
References & Citations
[1]Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376(6600):1471-1476.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147313/TH10785-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147313/TH10785-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1002801-51-5
Available Sizes
Curated Selection
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