TH10785

TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].

Product Specifications

CAS Number

[1002801-51-5]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/th10785.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1

Molecular Formula

C17H21N3

Molecular Weight

267.37

References & Citations

[1]Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376 (6600) :1471-1476.