TH10785
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
Product Specifications
CAS Number
1002801-51-5
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/th10785.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C1(N=C(C2CC2)N=C3NC4CCCCC4)=C3C=CC=C1
Molecular Formula
C17H21N3
Molecular Weight
267.37
References & Citations
[1]Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376 (6600) :1471-1476.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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