Triptohypol C
Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Product Specifications
CAS Number
[193957-88-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Nuclear Hormone Receptor 4A/NR4A; p62
Type
Natural Products
Related Pathways
Autophagy; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/triptohypol-c.html
Purity
96.56
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=C(O)C(O)=CC2=C1CC=C3[C@@]2(C)CC[C@]4(C)[C@]3(C)CC[C@]5(C)[C@@]4([H])C[C@](C)(C(O)=O)CC5
Molecular Formula
C29H40O4
Molecular Weight
452.63
Precautions
H302, H315, H319
References & Citations
[1]Chen Z, et al. SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem. 2019 Sep 1;177:171-187.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1
Available Sizes
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