Azaserine

Azazerine (CI-337) is a competitive inhibitor of glutamine amidotransferase. Azaserine is an antibiotic, it shows antibacterial activities. Azazerine shows anti-tumor activities and it may also act as a tumor inducer. Azazerine can be used for the research of cancer and infection[1][2][3][4][5].

Product Specifications

CAS Number

[115-02-6]

Product Name Alternative

CI-337; O-Diazoacetyl-L-serine; P-165

UNSPSC

12352211

Hazard Statement

H301, H351

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Azaserine.html

Purity

99.96

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](COC(C=[N+]=[N-])=O)C(O)=O

Molecular Formula

C5H7N3O4

Molecular Weight

173.13

Precautions

H301, H351

References & Citations

[1]Longnecker DS, Curphey TJ. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35 (8) :2249-58.|[2]Shigemichi GUNJI, et al. Screening of Antifungal Antibiotics According to Activities Inducing Morphological Abnormalities. Agric. Biol Chem., 47 (9), 2061-2069, 1983.|[3]Williams MV, Tritz GJ. Studies on the modes of action of azaserine inhibition of Escherichia coli. Potentiation of phenylalanine reversal. J Antimicrob Chemother. 1977 Jan;3 (1) :65-77.|[4]Catane R, et al. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity. Cancer Treat Rep. 1979 Jun;63 (6) :1033-8. |[5]Lyons SD, et al. Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia. J Biol Chem. 1990 Jul 5;265 (19) :11377-81.