(-) -Hydroxycitric acid lactone

(-) -Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-) -Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-) -Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis[1][2].

Product Specifications

CAS Number

[27750-13-6]

Product Name Alternative

Garcinia lactone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATP Citrate Lyase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/minus-hydroxycitric-acid-lactone.html

Purity

99.82

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O[C@](CC(O1)=O)(C(O)=O)[C@H]1C(O)=O

Molecular Formula

C6H6O7

Molecular Weight

190.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Han J, et al. (-) -Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related geneexpression in broiler chickens. Lipids Health Dis. 2016 Feb 24;15:37.|[2]Jena BS, et al. Chemistry and biochemistry of (-) -hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50 (1) :10-22.