Imidazoleacetic acid (hydrochloride)

Imidazoleacetic acid hydrochloride is a γ-aminobutyric acid receptor agonist. Imidazoleacetic acid hydrochloride inhibits GABA-T in a non-competitive manner, with a Ki value of 0.34 mM. Imidazoleacetic acid hydrochloride increases total free GABA in brain[1][2][3].

Product Specifications

CAS Number

[3251-69-2]

Product Name Alternative

Imidazolyl-4-acetic acid (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; GABA Receptor

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-1h-imidazol-5-yl-acetic-acid-hydrochloride.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(O)CC1=CN=CN1.[H]Cl

Molecular Formula

C5H7ClN2O2

Molecular Weight

162.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol (in) e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101 (37) :13677-82.|[2]Clifford JM, et al. Biochemical and pharmacological actions of imidazoleacetic acid. Biochem Pharmacol. 1973 Feb 15;22 (4) :535-42.|[3]Thomas B, et al. Imidazoleacetic acid, a gamma-aminobutyric acid receptor agonist, can be formed in rat brain by oxidation of histamine. J Neurochem. 1995 Aug;65 (2) :818-26.