STAT3-IN-36
Product Specifications
UNSPSC Description
STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and CDK1 with anticancer activity. STAT3-IN-36 binds to LRPPRC, STAT3, and CDK1, exerting a stronger anticancer effect than TMF (HY-N6818) or Capecitabine (HY-B0016). STAT3-IN-36 inhibits HGC27 cells with IC50 1.8 μM.[1].
Target Antigen
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-36.html
Smiles
O=S(C1=C(OC)C=C(OC)C2=C1OC(C3=CC=C(OC)C(S(=O)(NC4=CC=C(F)C=C4)=O)=C3)=CC2=O)(NC5=CC=C(F)C=C5)=O
Molecular Weight
658.65
References & Citations
[1]Wu R, et al. Design, synthesis, and biological evaluation of novel 5,7,4'-trimethoxyflavone sulfonamide-based derivatives as highly potent inhibitors of LRPPRC/STAT3/CDK1. Bioorg Chem. 2024 Dec;153:107878.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168519/STAT3-IN-36-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168519/
Clinical Information
No Development Reported
CAS Number
3055766-74-7
Curated Selection
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