Amino-PEG4-CH2COOH
Amino-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Amino-PEG4-CH2COOH is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
Product Specifications
CAS Number
[195071-49-9]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amino-peg4-ch2cooh.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)COCCOCCOCCOCCN
Molecular Formula
C10H21NO6
Molecular Weight
251.28
Precautions
H302, H315, H319, H335
References & Citations
[1]Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.|[2]Maggie Lu, et al. Linker-drug and antibody-drug conjugate (adc) employing the same. EP3335734A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
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