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Numb (phospho-Ser276) rabbit pAb

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Product Specifications

Background

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Synonyms

Protein numb homolog (h-Numb) (Protein S171)

Gene ID

8650

UniProt

P49757

Cellular Locus

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side. Localizes to perinuclear endosomes in an AAK1-dependent manner..

Host

Rabbit

Species Reactivity

Human,Rat,Mouse,

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized phosho peptide around human Numb (Ser276)

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB

Validated Applications

WB

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1:1000-2000

Molecular Weight

70kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14425-1.pdf

Observed Molecular Weight

70 kD

Subcellular Location

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .

Other Product Names

Protein numb homolog (h-Numb) (Protein S171)

Gene ID (Human)

8650

SwissProt (Human)

P49757

Available Sizes

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