2-Ketoglutaric acid

2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) [1].

Product Specifications

CAS Number

[328-50-7]

Product Name Alternative

Alpha-Ketoglutaric acid; 2-Oxoglutaric acid

UNSPSC

12352211

Hazard Statement

H314, H318

Target

Endogenous Metabolite; Tyrosinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-Ketoglutaric_acid.html

Purity

99.90

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C(O)=O)CCC(O)=O

Molecular Formula

C5H6O5

Molecular Weight

146.10

Precautions

H314, H318

References & Citations

[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.