Zederone

Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6) . Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin (HY-121544) -resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis[1][2][3][4][5][6].

Product Specifications

CAS Number

[7727-79-9]

UNSPSC

12352005

Target

Bacterial; mTOR; Ribosomal S6 Kinase (RSK)

Type

Natural Products

Related Pathways

Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zederone.html

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=COC(C/C(C)=C/CC[C@]2(C)[C@@]3([H])O2)=C1C3=O

Molecular Formula

C15H18O3

Molecular Weight

246.30

References & Citations

[1]Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32 (6) :454-62.|[2]Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25 (2) :785-791.|[3]Pimkaew P, et al. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27 (6) :2005-12.|[4]Kader M G, et al. Zederone from the rhizomes of Zingiber zerumbet and its anti-staphylococcal activity[J]. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2010, 9 (1) : 63-68.|[5]Anuchapreeda S, et al. Characterization and biological properties of zederone and zedoarondiol from rhizomes of En-lueang (Curcuma cf. Amada) [J]. Natural Product Communications, 2018, 13 (12) .|[6]Borah S, Sarkar P, Sharma HK. Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report. CNS Neurol Disord Drug Targets. 2022;21 (4) :335-342.