What is the catalog number for Zederone?

The catalog number for Zederone is HY-N1050.

What sizes are available for Zederone?

Zederone is available in the following size(s): 5 mg, 10 mg.

How many pack sizes does Zederone come in?

Zederone is available in 2 different pack sizes.

Is Zederone in stock?

Zederone is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Zederone?

Zederone is manufactured by QuantiMol.

What is the estimated delivery time for Zederone?

Estimated delivery time for Zederone is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Zederone?

The safety data sheet for Zederone is available here: http://file.medchemexpress.com/batch_PDF/HY-N1050/Zederone-SDS-MedChemExpress.pdf.

Zederone

Zederone is a sesquiterpene. Zederone inhibits ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. Zederone inhibits CYP activities with IC50s of 2.9 μM (CYP2B6), 9.2 μM (CYP2C9), 11,2 μM (CYP2C19) and >30 μM (CYP1A2 and CYP2D6). Zederone is hepatotoxic with LD50 value at 24 hours in mice of approximately 223 mg/kg and cytotoxic against the KG1a cell line. Zederone shows antibacterial activity against a number of multi-drug resistant and Methicillin -resistant Staphylococcus aureus strain. Zederone shows cognition improving capacity and assists in the modulation of gut bacterial dysbiosis[1][2][3][4][5][6].

Product Specifications

CAS Number

7727-79-9

UNSPSC

12352005

Target

Bacterial; mTOR; Ribosomal S6 Kinase (RSK)

Type

Natural Products

Related Pathways

Anti-infection; MAPK/ERK Pathway; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/zederone.html

Purity

99.61

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=COC(C/C(C)=C/CC[C@]2(C)[C@@]3([H])O2)=C1C3=O

Molecular Formula

C15H18O3

Molecular Weight

246.30

References & Citations

[1]Prapapan Pimkaew, et al. Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice. Int J Toxicol. 2013 Nov-Dec;32 (6) :454-62.|[2]Zhilei Zhang, et al. A study of zederone for the inhibition on ovarian cancer cell proliferation through mTOR/p70s6K signalling pathway. J BUON. 2020 Mar-Apr;25 (2) :785-791.|[3]Pimkaew P, et al. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27 (6) :2005-12.|[4]Kader M G, et al. Zederone from the rhizomes of Zingiber zerumbet and its anti-staphylococcal activity[J]. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 2010, 9 (1) : 63-68.|[5]Anuchapreeda S, et al. Characterization and biological properties of zederone and zedoarondiol from rhizomes of En-lueang (Curcuma cf. Amada) [J]. Natural Product Communications, 2018, 13 (12) .|[6]Borah S, Sarkar P, Sharma HK. Zederone Improves the Fecal Microbial Profile in Dementia Induced Rat Model: A First Report. CNS Neurol Disord Drug Targets. 2022;21 (4) :335-342.