Mexiletine

Mexiletine is an orally effective antiarrhythmic agent which has also been found to be effective for myotonia and neuropathic pain. Mexiletine exerts its efficacy through blocking sodium channels (IC50 : 75±8 μM for tonic block, 23.6±2.8 μM for use-dependent block), therefore can be used for cardiovascular and neurological research[1][2][3][4][5].

Product Specifications

CAS Number

[31828-71-4]

Product Name Alternative

KOE-1173

UNSPSC

12352005

Hazard Statement

H302

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/mexiletine.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : ≥ 175 mg/mL

Smiles

CC(COC1=C(C=CC=C1C)C)N

Molecular Formula

C11H17NO

Molecular Weight

179.26

Precautions

H302

References & Citations

[1]Campbell RW, et al. Mexiletine. N Engl J Med. 1987, 316 (1) :29-34.|[2]De Bellis M, et al. Combined modifications of mexiletine pharmacophores for new lead blockers of Na (v) 1.4 channels. Biophys J. 2013, 104 (2) :344-54.|[3]Nasilli G, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010;112 (4) :473-6.|[4]Egashira N, et al. Mexiletine reverses oxaliplatin-induced neuropathic pain in rats. J Pharmacol Sci. 2010, 112 (4) :473-6.