Pyrimidyn 7
Pyrimidyn 7 is an inhibitor of dynamin I/II with IC50 values of 1.1 μM and 1.8 μM, respectively. Pyrimidyn 7 competitively inhibits the interactions between GTP and phospholipids with dynamin I. Additionally, Pyrimidyn 7 reversibly inhibits clathrin-mediated endocytosis (CME) of transferrin and epidermal growth factor (EGF) in various non-neuronal cell linecell[1.
Product Specifications
CAS Number
[1440126-94-2]
UNSPSC
12352005
Target
Dynamin
Type
Reference compound
Related Pathways
Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pyrimidyn-7.html
Smiles
CC1=CC(NCCCCCCCCCCCC)=NC(NCCN(C)C)=N1
Molecular Formula
C21H41N5
Molecular Weight
363.58
References & Citations
[1]McGeachie AB, et al. Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chem Biol. 2013 Jul 19;8 (7) :1507-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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