Bivamelagon
Bivamelagon (MC-4R Agonist 2) is an orally active and BBB-penetrable MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon can be used for the research of diseases such as obesity and diabetes[1].
Product Specifications
CAS Number
[2641595-54-0]
Product Name Alternative
MC-4R Agonist 2
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bivamelagon.html
Purity
99.50
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O
Molecular Formula
C35H53ClN4O4
Molecular Weight
629.27
References & Citations
[1]Seung Wan Kang, et al. Melanocortin-4 receptor agonists. Patent WO2021091283A1. 2021-05-14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MC4R
Available Sizes
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