BF-1

BF-1 is a 5-HT2B receptor antagonist with a pKi value of 10.05 and an IC50 value of 2.6 nM[1].

Product Specifications

CAS Number

[518980-66-0]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bf-1.html

Smiles

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC(OCC)=C4)C=CC=C3OC

Molecular Formula

C22H25NO2S

Molecular Weight

367.50

References & Citations

[1]Beate Schmitz, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15:751:73-80.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

5-HT2 Receptor

Available Sizes

Curated Selection

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