(S) -CE-123
(S) -CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S) -CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S) -CE-123 improves cognitive and motivational processes in experimental animals[1][2].
Product Specifications
CAS Number
2378384-49-5
UNSPSC
12352005
Target
Dopamine Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-ce-123.html
Solubility
10 mM in DMSO
Smiles
O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C17H15NOS2
Molecular Weight
313.44
References & Citations
[1]Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S) -CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. |[2]Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S) -CE-123. ACS Omega 2024, March 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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