(S) -CE-123
(S) -CE-123 is a potent, selective, and novel atypical dopamine transporter (DAT) inhibitor with an EC50 of 2.76 μM in uptake inhibition assays conducted in HEK293 cells stably expressing human isoforms of DAT. (S) -CE-123, a Modafinil analogue, is able to penetrate the blood–brain barrier. (S) -CE-123 improves cognitive and motivational processes in experimental animals[1][2].
Product Specifications
CAS Number
2378384-49-5
UNSPSC
12352005
Target
Dopamine Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-ce-123.html
Solubility
10 mM in DMSO
Smiles
O=[S@@](CC1=CN=CS1)C(C2=CC=CC=C2)C3=CC=CC=C3
Molecular Formula
C17H15NOS2
Molecular Weight
313.44
References & Citations
[1]Renee A Rotolo, et al. The Novel Atypical Dopamine Uptake Inhibitor (S) -CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding. Front Pharmacol. 2019 Jun 28:10:682. |[2]Eduardo R. Perez Gonzalez, et al. Process Development and Scale-Up of a Novel Atypical DAT Inhibitor (S) -CE-123. ACS Omega 2024, March 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC942153-100 1x 100 µL
TACSTD2 / TROP2 (Epithelial Marker) (TACSTD2/2153), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details