(S) -β-Aminoisobutyric acid

(S) -β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974) . (S) -β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S) -β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S) -β-Aminoisobutyric acid has cardioprotective effects. (S) -β-Aminoisobutyric acid is associated with acute aerobic exercise[1][2][3].

Product Specifications

CAS Number

[4249-19-8]

Product Name Alternative

9-Amino-20(S)-camptothecin; 9-Amino-CPT

UNSPSC

12352211

Hazard Statement

H225

Target

AMPK; Apoptosis; Drug Isomer; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease; Inflammation/Immunology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/_S_-b-aminoisobutyric_acid.html

Purity

99.59

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](C)CN

Molecular Formula

C4H9NO2

Molecular Weight

103.12

Precautions

H225

References & Citations

[1]CRUMPLER HR, et al. beta-Aminoisobutyric acid (alpha-methyl-beta-alanine) ; a new amino-acid obtained from human urine. Nature. 1951 Feb 24;167 (4243) :307-8.|[2]Yu Y, et al. Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway. Front Cardiovasc Med. 2022 Feb 25;9:803510. |[3]Stautemas J, et al. Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans. Front Physiol. 2019 Sep 25;10:1240.