Compound 48/80 (trihydrochloride)

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets [1][2][3].

Product Specifications

CAS Number

[848035-21-2]

Product Name Alternative

C48/80 (trihydrochloride)

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/compound-48-80-trihydrochloride.html

Concentration

10mM

Purity

99.95

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C32H48Cl3N3O3

Molecular Weight

629.10

Precautions

H301+H311+H331

References & Citations

[1]Bronner C, et al. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim Biophys Acta. 1987 Aug 15;920 (3) :301-5.|[2]Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7 (12) :e52104.|[3]Kaida S, et al. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation. Free Radic Res. 2010 Feb;44 (2) :171-80.