VMAT2-IN-4
VMAT2-IN-4 (compound 11) is a vesicular monoamine transporter-2 (VMAT2) inhibitor. VMAT2-IN-4 inhibits [3H]-DTBZ binding (Ki = 560 nM) . VMAT2-IN-4 inhibits [3H]-DA (Ki = 45 nM) from entering vesicles and being taken up by cells. VMAT2-IN-4 can be used in methamphetamine addiction research[1].
Product Specifications
CAS Number
1436695-49-6
UNSPSC
12352005
Target
Monoamine Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vmat2-in-4.html
Smiles
OC[C@H](O)CN1[C@@H](CCC2=CC=C(OC(F)F)C=C2)CC[C@H]1CCC3=CC=C(OC(F)F)C=C3.[H]Cl
Molecular Formula
C25H32ClF4NO4
Molecular Weight
521.97
References & Citations
[1]Penthala NR, et al. Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2) . Bioorg Med Chem Lett. 2013 Jun 1;23 (11) :3342-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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